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Publikationer

Forskningsartiklar

  1. Edstorp, J., Wei, Y., Ahlqvist, E., Alfredsson, L., Grill, V., Groop, L., Rasouli, B., Sørgjerd, E. P., Thorsby, P. M., Tuomi, T., Åsvold, B. O., & Carlsson, S. (2023). Smoking, use of smokeless tobacco, HLA genotypes and incidence of latent autoimmune diabetes in adults. Diabetologia, 66(1), 70–81. https://doi.org/10.1007/s00125-022-05763-w
  2. Christensen DH, Nicolaisen SK, Ahlqvist E, Stidsen JV, Nielsen JS, Hojlund K, Olsen MH, García-Calzón S, Ling C, Rungby J, Brandslund I, Vestergaard P, Jessen N, Hansen T, Brøns C, Beck-Nielsen H, Sørensen HT, Thomsen RW, Vaag A. Type 2 diabetes classification: a data-driven cluster study of the Danish Centre for Strategic Research in Type 2 Diabetes (DD2) cohort. BMJ Open Diabetes Res Care. 2022 Apr;10(2):e002731. DOI: 10.1136/bmjdrc-2021-002731  . PMID: 35428673; PMCID: PMC9014045.
  3. Deutsch, A. J., Ahlqvist, E., & Udler, M. S. (2022). Phenotypic and genetic classification of diabetes. Diabetologia, 65(11), 1758–1769. https://doi.org/10.1007/s00125-022-05769-4
  4. Drake I, Fryk E, Strindberg L, Lundqvist A, Rosengren AH, Groop L, Ahlqvist E, Borén J, Orho-Melander M, Jansson PA. The role of circulating galectin-1 in type 2 diabetes and chronic kidney disease: evidence from cross-sectional, longitudinal and Mendelian randomisation analyses. Diabetologia. 2022 Jan;65(1):128-139. https://doi.org/10.1007/s00125-021-05594-1. Epub 2021 Nov 7. PMID: 34743218; PMCID: PMC8660752.
  5. Dwibedi, C., Abrahamsson, B., & Rosengren, A. H. (2022). Effect of Digital Lifestyle Management on Metabolic Control and Quality of Life in Patients with Well-Controlled Type 2 Diabetes. Diabetes therapy: research, treatment and education of diabetes and related disorders, 13(3), 423–439. https://doi.org/10.1007/s13300-022-01214-2
  6. Schrader S, Perfilyev A, Ahlqvist E, Groop L, Vaag A, Martinell M, et al. Novel Subgroups of Type 2 Diabetes Display Different Epigenetic Patterns, Which Associate With Future Diabetic Complications. https://doi.org/10.2337/dc21-2489 Diabetes Care. 2022.
  7. Dwibedi C, Abrahamsson B, Rosengren AH. Effect of Digital Lifestyle Management on Metabolic Control and Quality of Life in Patients with Well-Controlled Type 2 Diabetes. Diabetes Therapy. 2022;13(3):423-39. https://doi.org/10.1007/s13300-022-01214-2
  8. Landgraf, W., Bigot, G., Hess, S., Asplund, O., Groop, L., Ahlqvist, E., Käräjämäki, A., Owens, D. R., Frier, B. M., & Bolli, G. B. (2022). Distribution and characteristics of newly-defined subgroups of type 2 diabetes in randomised clinical trials: Post hoc cluster assignment analysis of over 12,000 study participants. Diabetes research and clinical practice, 190, 110012. https://doi.org/10.1016/j.diabres.2022.110012
  9. Prasad RB, Asplund O, Shukla SR, Wagh R, Kunte P, Bhat D, Parekh M, Shah M, Phatak S, Käräjämäki A, Datta A, Kakati S, Tuomi T, Saboo B, Ahlqvist E, Groop L, Yajnik CS. Subgroups of patients with young-onset type 2 diabetes in India reveal insulin deficiency as a major driver. Diabetologia. 2022 Jan;65(1):65-78. doi: 10.1007/s00125-021-05543-y. Epub 2021 Oct 23. Erratum in: Diabetologia. 2021 Nov 22;: PMID: 34689214; PMCID: PMC8660725.
  10. Zaghlool, S. B., Halama, A., Stephan, N., Gudmundsdottir, V., Gudnason, V., Jennings, L. L., Thangam, M., Ahlqvist, E., Malik, R. A., Albagha, O. M. E., Abou-Samra, A. B., & Suhre, K. (2022). Metabolic and proteomic signatures of type 2 diabetes subtypes in an Arab population. Nature communications, 13(1), 7121. https://doi.org/10.1038/s41467-022-34754-z
  11. Mansour Aly D, Dwivedi OP, Prasad RB, Käräjämäki A, Hjort R, Thangam M, Åkerlund M, Mahajan A, Udler MS, Florez JC, McCarthy MI; Regeneron Genetics Center, Brosnan J, Melander O, Carlsson S, Hansson O, Tuomi T, Groop L, Ahlqvist E. Genome-wide association analyses highlight etiological differences underlying newly defined subtypes of diabetes. Nat Genet. 2021 Nov;53(11):1534-1542. doi: 10.1038/s41588-021-00948-2. Epub 2021 Nov 4. PMID: 34737425.
  12. Slieker RC, Donnelly LA, Fitipaldi H, Bouland GA, Giordano GN, Åkerlund M, Gerl MJ, Ahlqvist E, Ali A, Dragan I, Festa A, Hansen MK, Mansour Aly D, Kim M, Kuznetsov D, Mehl F, Klose C, Simons K, Pavo I, Pullen TJ, Suvitaival T, Wretlind A, Rossing P, Lyssenko V, Legido-Quigley C, Groop L, Thorens B, Franks PW, Ibberson M, Rutter GA, Beulens JWJ, 't Hart LM, Pearson ER. Replication and cross-validation of type 2 diabetes subtypes based on clinical variables: an IMI-RHAPSODY study. Diabetologia. 2021 Sep;64(9):1982-1989. doi: 10.1007/s00125-021-05490-8. Epub 2021 Jun 10. PMID: 34110439; PMCID: PMC8382625.
  13. Bennet L, Nilsson C, Mansour-Aly D, Christensson A, Groop L, Ahlqvist E. Adult-onset diabetes in Middle Eastern immigrants to Sweden: Novel subgroups and diabetic complications-The All New Diabetes in Scania cohort diabetic complications and ethnicity. Diabetes Metab Res Rev. 2021 Sep;37(6):e3419. doi: 10.1002/dmrr.3419. Epub 2020 Nov 6. PMID: 33119194; PMCID: PMC8518927.
  14. Schrader S, Perfilyev A, Martinell M, García-Calzón S, Ling C. Statin therapy is associated with epigenetic modifications in individuals with Type 2 diabetes. Epigenomics. 2021 Jun;13(12):919-925. doi: 10.2217/epi-2020-0442. Epub 2021 May 5. PMID: 33947200.
  15. Mellergård E, Johnsson P, Eek F. Developing a web-based support using self-affirmation to motivate lifestyle changes in type 2 diabetes: A qualitative study assessing patient perspectives on self-management and views on a digital lifestyle intervention. Internet Interv. 2021 Mar 31;24:100384. doi: 10.1016/j.invent.2021.100384. PMID: 33912400; PMCID: PMC8056219.
  16. Simonsen JR, Käräjämäki A, Antikainen AA, Toppila I, Ahlqvist E, Prasad R, Mansour-Aly D, Harjutsalo V, Järvinen A, Tuomi T, Groop L, Forsblom C, Groop PH, Sandholm N, Lehto M. Genetic factors affect the susceptibility to bacterial infections in diabetes. Sci Rep. 2021 May 4;11(1):9464. doi: 10.1038/s41598-021-88273-w. PMID: 33947878; PMCID: PMC8096814.
  17. Slieker RC, Donnelly LA, Fitipaldi H, Bouland GA, Giordano GN, Åkerlund M, et al. Distinct Molecular Signatures of Clinical Clusters in People with Type 2 Diabetes: an IMIRHAPSODY Study. Diabetes. 2021. doi: 10.2339/db20-1281 
  18. Lofvenborg JE, Ahlqvist E, Alfredsson L, Andersson T, Groop L, Tuomi T, et al. Consumption of red meat, genetic susceptibility, and risk of LADA and type 2 diabetes. Doi: 10-1007/s00394-020-02285-2. European journal of nutrition. 2021;60(2):769-79.
  19. Herzog K, Ahlqvist E, Alfredsson L, Groop L, Hjort R, Lofvenborg JE, et al. Combined lifestyle factors and the risk of LADA and type 2 diabetes - Results from a Swedish population-based case-control study. Doi: 10.1016/j.diabres.2021.108760. Diabetes research and clinical practice. 2021;174:108760.
  20. Mishra R, Akerlund M, Cousminer DL, Ahlqvist E, Bradfield JP, Chesi A, et al. Genetic Discrimination Between LADA and Childhood-Onset Type 1 Diabetes Within the MHC. Doi: 10.2337/dc19-0986. Diabetes Care. 2020;43(2):418-25.
  21. Lofvenborg JE, Ahlqvist E, Alfredsson L, Andersson T, Dorkhan M, Groop L, et al. Genotypes of HLA, TCF7L2, and FTO as potential modifiers of the association between sweetened beverage consumption and risk of LADA and type 2 diabetes. Doi: 10.1007/s00394-019-01893-x. European journal of nutrition. 2020;59(1):127-35.
  22. Hjort R, Ahlqvist E, Andersson T, Alfredsson L, Carlsson PO, Grill V, et al. Physical Activity, Genetic Susceptibility, and the Risk of Latent Autoimmune Diabetes in Adults and Type 2 Diabetes. DOI: 10.1210/clinem/dgaa549.  J Clin Endocrinol Metab. 2020;105(11).
  23. Garcia-Calzon S, Perfilyev A, Martinell M, Ustinova M, Kalamajski S, Franks PW, et al. Epigenetic markers associated with metformin response and intolerance in drug-naive patients with type 2 diabetes. DOI: 10.1126/scitranslmed.aaz.1803. Science translational medicine. 2020;12(561).
  24. Hjort R, Lofvenborg JE, Ahlqvist E, Alfredsson L, Andersson T, Grill V, et al. Interaction Between Overweight and Genotypes of HLA, TCF7L2, and FTO in Relation to the Risk of Latent Autoimmune Diabetes in Adults and Type 2 Diabetes. Doi: 10.1210/jc.2019-00183. J Clin Endocrinol Metab. 2019;104(10):4815-26.
  25. Hjort R, Ahlqvist E, Carlsson PO, Grill V, Groop L, Martinell M, Rasouli B, Rosengren A, Tuomi T, Åsvold BO, Carlsson S. Overweight, obesity and the risk of LADA: results from a Swedish case-control study and the Norwegian HUNT Study. Diabetologia. 2018 Jun;61(6):1333-1343. doi: 10.1007/s00125-018-4596-0. Epub 2018 Mar 27. PMID: 29589073; PMCID: PMC6448998.
  26. Ahlqvist E, Storm P, Käräjämäki A, Martinell M, Dorkhan M, Carlsson A, Vikman P, Prasad RB, Aly DM, Almgren P, Wessman Y, Shaat N, Spégel P, Mulder H, Lindholm E, Melander O, Hansson O, Malmqvist U, Lernmark Å, Lahti K, Forsén T, Tuomi T, Rosengren AH, Groop L. Novel subgroups of adult-onset diabetes and their association with outcomes: a data-driven cluster analysis of six variables. Lancet Diabetes Endocrinol. 2018 May;6(5):361-369. doi: 10.1016/S2213-8587(18)30051-2. Epub 2018 Mar 5. PMID: 29503172.
  27. Rasouli B, Ahlqvist E, Alfredsson L, Andersson T, Carlsson PO, Groop L, et al. Coffee consumption, genetic susceptibility and risk of latent autoimmune diabetes in adults: A population-based case-control study. doi: 10.1016/j.diabet.2018.05.002. Diabetes & metabolism. 2018;44(4):354-60.
  28. Cousminer DL, Ahlqvist E, Mishra R, Andersen MK, Chesi A, Hawa MI, et al. First Genome-Wide Association Study of Latent Autoimmune Diabetes in Adults Reveals Novel Insights Linking Immune and Metabolic Diabetes. Doi: 10.2337/dc18-1032. Diabetes Care. 2018;41(11):2396-403.
  29. Rasouli B, Andersson T, Carlsson PO, Hjort R, Lofvenborg JE, Martinell M, et al. Serious life events and the risk of latent autoimmune diabetes in adults (LADA) and Type 2 diabetes. Doi: 10.1111/dme.13410. Diabet Med. 2017;34(9):1259-63.
  30. Al-Majdoub M, Ali A, Storm P, Rosengren AH, Groop L, Spegel P. Metabolite Profiling of LADA Challenges the View of a Metabolically Distinct Subtype. Doi: 10.2337/dd16-0779. Diabetes. 2017;66(4):806-14.
  31. Martinell M, Pingel R, Hallqvist J, Dorkhan M, Groop L, Rosengren A, Storm P, Stålhammar J. Education, immigration and income as risk factors for hemoglobin A1c >70 mmol/mol when diagnosed with type 2 diabetes or latent autoimmune diabetes in adult: a population-based cohort study. BMJ Open Diabetes Res Care. 2017 May 8;5(1):e000346. doi: 10.1136/bmjdrc-2016-000346. PMID: 28761648; PMCID: PMC5530247.
  32. Scott RA, Scott LJ, Mägi R, Marullo L, Gaulton KJ, Kaakinen M, Pervjakova N, Pers TH, Johnson AD, Eicher JD, Jackson AU, Ferreira T, Lee Y, Ma C, Steinthorsdottir V, Thorleifsson G, Qi L, Van Zuydam NR, Mahajan A, Chen H, Almgren P, Voight BF, Grallert H, Müller-Nurasyid M, Ried JS, Rayner NW, Robertson N, Karssen LC, van Leeuwen EM, Willems SM, Fuchsberger C, Kwan P, Teslovich TM, Chanda P, Li M, Lu Y, Dina C, Thuillier D, Yengo L, Jiang L, Sparso T, Kestler HA, Chheda H, Eisele L, Gustafsson S, Frånberg M, Strawbridge RJ, Benediktsson R, Hreidarsson AB, Kong A, Sigurðsson G, Kerrison ND, Luan J, Liang L, Meitinger T, Roden M, Thorand B, Esko T, Mihailov E, Fox C, Liu CT, Rybin D, Isomaa B, Lyssenko V, Tuomi T, Couper DJ, Pankow JS, Grarup N, Have CT, Jørgensen ME, Jørgensen T, Linneberg A, Cornelis MC, van Dam RM, Hunter DJ, Kraft P, Sun Q, Edkins S, Owen KR, Perry JRB, Wood AR, Zeggini E, Tajes-Fernandes J, Abecasis GR, Bonnycastle LL, Chines PS, Stringham HM, Koistinen HA, Kinnunen L, Sennblad B, Mühleisen TW, Nöthen MM, Pechlivanis S, Baldassarre D, Gertow K, Humphries SE, Tremoli E, Klopp N, Meyer J, Steinbach G, Wennauer R, Eriksson JG, Mӓnnistö S, Peltonen L, Tikkanen E, Charpentier G, Eury E, Lobbens S, Gigante B, Leander K, McLeod O, Bottinger EP, Gottesman O, Ruderfer D, Blüher M, Kovacs P, Tonjes A, Maruthur NM, Scapoli C, Erbel R, Jöckel KH, Moebus S, de Faire U, Hamsten A, Stumvoll M, Deloukas P, Donnelly PJ, Frayling TM, Hattersley AT, Ripatti S, Salomaa V, Pedersen NL, Boehm BO, Bergman RN, Collins FS, Mohlke KL, Tuomilehto J, Hansen T, Pedersen O, Barroso I, Lannfelt L, Ingelsson E, Lind L, Lindgren CM, Cauchi S, Froguel P, Loos RJF, Balkau B, Boeing H, Franks PW, Barricarte Gurrea A, Palli D, van der Schouw YT, Altshuler D, Groop LC, Langenberg C, Wareham NJ, Sijbrands E, van Duijn CM, Florez JC, Meigs JB, Boerwinkle E, Gieger C, Strauch K, Metspalu A, Morris AD, Palmer CNA, Hu FB, Thorsteinsdottir U, Stefansson K, Dupuis J, Morris AP, Boehnke M, McCarthy MI, Prokopenko I; DIAbetes Genetics Replication And Meta-analysis (DIAGRAM) Consortium. An Expanded Genome-Wide Association Study of Type 2 Diabetes in Europeans. Diabetes. 2017 Nov;66(11):2888-2902. doi: 10.2337/db16-1253. Epub 2017 May 31. PMID: 28566273; PMCID: PMC5652602.
  33. Rasouli B, Andersson T, Carlsson PO, Grill V, Groop L, Martinell M, et al. Smoking and the Risk of LADA: Results From a Swedish Population-Based Case-Control Study. Doi: 10.2337/dc15-2348. Diabetes Care. 2016;39(5):794-800.
  34. Martinell M, Dorkhan M, Stalhammar J, Storm P, Groop L, Gustavsson C. Prevalence and risk factors for diabetic retinopathy at diagnosis (DRAD) in patients recently diagnosed with type 2 diabetes (T2D) or latent autoimmune diabetes in the adult (LADA). Doi: 10.1016/j.jdiacomp.2016.08.2009. J Diabetes Complications. 2016;30(8):1456-61.
  35. Gaulton, Kyle J et al. “Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci.” Nature genetics vol. 47,12 (2015): 1415-25. doi:10.1038/ng.3437
  36. Rasouli, Bahareh et al. “Alcohol and the risk for latent autoimmune diabetes in adults: results based on Swedish ESTRID study.” European journal of endocrinology vol. 171,5 (2014): 535-43. doi:10.1530/EJE-14-0403
  37. Lofvenborg, J. E., Andersson, T., Carlsson, P. -O., Dorkhan, M., Groop, L., Martinell, M., Rasouli, B., Storm, P., Tuomi, T., & Carlsson, S. (2014). Coffee consumption and the risk of latent autoimmune diabetes in adults-results from a Swedish case-control study. Diabetic Medicine, 31(7), 799-805. https://doi.org/10.1111/dme.12469
  38. Groop, Leif et al. “Can genetics improve precision of therapy in diabetes?.” Trends in endocrinology and metabolism: TEM vol. 25,9 (2014): 440-3. doi:10.1016/j.tem.2014.06.005

Reviewartiklar:

  1. Ahlqvist E, Prasad RB, Groop L. Towards improved precision and a new classification of diabetes mellitus. Doi: 10.1530/JOE-20-20-0596. J Endocrinol. 2021 Dec 20;252(3):R59-R70
  2. Ahlqvist E, Prasad RB, Groop L. Subtypes of Type 2 Diabetes Determined From Clinical Parameters. Doi: 10.2337/dbi20-0001.Diabetes. 2020;69(10):2086-93.
  3. Prasad, R.B., E. Ahlqvist, and L. Groop, Heterogeneity of diabetes - An Indian perspective. Doi:10.1016/j.dsx.2018.07.001. Diabetes and Metabolic Syndome, 2019.

Avhandlingar:

Dina Mansour, Jan 2022, Genetics of Diabetes Subtypes. Characterization of novel cluster-based diabetes subtypes.

C Nilsson, December 2021, Aspects of ethnicity on blood pressure regulating mechanisms and kidney function in a defined population.

Olof Asplund, Data integration and visualization in type 2 diabetes research and care: From biological mechanisms to precision medicine. Lund University (2021).

Övriga publikationer

1.      Ahlqvist E, Tuomi T & Groop L. Clusters provide a better holistic view of type 2 diabetes than simple clinical features, 2019, Lancet Diabetes and Endocrinol 7(9), p. 668-669.

2.      Ahlqvist, E., R.B. Prasad, T. Tuomi, A. Rosengren, and L. Groop, Novel diabetes subgroups - Authors' reply. Lancet Diabetes Endocrinol, 2018. 6(6): p. 440-441.

 

Senast uppdaterad: 2024-03-01 | ulrika [dot] blom-nilsson [at] med [dot] lu [dot] se